3-Acetylindole

Synonym(s):3-Indolyl methyl ketone;NSC 47180;NSC 58084

CAS NO.：703-80-0
Empirical Formula: C10H9NO
Molecular Weight: 159.18
MDL number: MFCD00005626
EINECS: 211-875-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-27 08:46:37

What is 3-Acetylindole?

Chemical properties

yellow to light brown powder

The Uses of 3-Acetylindole

3-Acetylindole can be used as anti-fungal agents.

The Uses of 3-Acetylindole

Reactant for preparation of:• ;Indole derivatives as antitumor agents1• ;Endothelin-1 antagonists2• ;Oncrasin-1 derivatives as inhibitors of the C-terminal domain of RNA polymerase II with antitumor activities3• ;Inhibitors of hepatitis C NS3/4A serine protease4• ;Antibacterial agens against MDR Staphylococcus aureus strains5• ;Antimalarial agents6• ;Anti-bovine viral diarrhea virus (BVDV) agents7• ;HIV-1 integrase inhibitors8• ;Inhibitors of NF-κB transcription regulation related to TNF-α cytokine release9

The Uses of 3-Acetylindole

Reactant for preparation of:

Indole derivatives as antitumor agents
Endothelin-1 antagonists
Oncrasin-1 derivatives as inhibitors of the C-terminal domain of RNA polymerase II with antitumor activities
Inhibitors of hepatitis C NS3/4A serine protease
Antibacterial agens against MDR Staphylococcus aureus strains
Antimalarial agents
Anti-bovine viral diarrhea virus (BVDV) agents
HIV-1 integrase inhibitors
Inhibitors of NF-κB transcription regulation related to TNF-α cytokine release

Purification Methods

Recrystallise the indole from MeOH or *C6H6 containing a little EtOH. The phenylureido derivative has m 154o. [Baker J Chem Soc 461 1946, Beilstein 21/8 V 297.]

Properties of 3-Acetylindole

Melting point:	188-192 °C (lit.)
Boiling point:	284.68°C (rough estimate)
Density	1.1202 (rough estimate)
refractive index	1.6070 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO; Dichloromethane; Methanol;
form	Powder
pka	15.38±0.30(Predicted)
color	Yellow to light brown
BRN	122579
CAS DataBase Reference	703-80-0(CAS DataBase Reference)
NIST Chemistry Reference	Ethanone, 1-(1h-indol-3-yl)-(703-80-0)

Safety information for 3-Acetylindole

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool.