3-Acetylindole
Synonym(s):3-Indolyl methyl ketone;NSC 47180;NSC 58084
- CAS NO.：703-80-0
- Empirical Formula: C10H9NO
- Molecular Weight: 159.18
- MDL number: MFCD00005626
- EINECS: 211-875-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-01 19:06:17
What is 3-Acetylindole?
Chemical properties
yellow to light brown powder
The Uses of 3-Acetylindole
3-Acetylindole can be used as anti-fungal agents.
The Uses of 3-Acetylindole
Reactant for preparation of:• ;Indole derivatives as antitumor agents1• ;Endothelin-1 antagonists2• ;Oncrasin-1 derivatives as inhibitors of the C-terminal domain of RNA polymerase II with antitumor activities3• ;Inhibitors of hepatitis C NS3/4A serine protease4• ;Antibacterial agens against MDR Staphylococcus aureus strains5• ;Antimalarial agents6• ;Anti-bovine viral diarrhea virus (BVDV) agents7• ;HIV-1 integrase inhibitors8• ;Inhibitors of NF-κB transcription regulation related to TNF-α cytokine release9
The Uses of 3-Acetylindole
Reactant for preparation of:
- Indole derivatives as antitumor agents
- Endothelin-1 antagonists
- Oncrasin-1 derivatives as inhibitors of the C-terminal domain of RNA polymerase II with antitumor activities
- Inhibitors of hepatitis C NS3/4A serine protease
- Antibacterial agens against MDR Staphylococcus aureus strains
- Antimalarial agents
- Anti-bovine viral diarrhea virus (BVDV) agents
- HIV-1 integrase inhibitors
- Inhibitors of NF-κB transcription regulation related to TNF-α cytokine release
Purification Methods
Recrystallise the indole from MeOH or *C6H6 containing a little EtOH. The phenylureido derivative has m 154o. [Baker J Chem Soc 461 1946, Beilstein 21/8 V 297.]
Properties of 3-Acetylindole
| Melting point: | 188-192 °C (lit.) |
| Boiling point: | 284.68°C (rough estimate) |
| Density | 1.1202 (rough estimate) |
| refractive index | 1.6070 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO; Dichloromethane; Methanol; |
| form | Powder |
| pka | 15.38±0.30(Predicted) |
| color | Yellow to light brown |
| BRN | 122579 |
| CAS DataBase Reference | 703-80-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 1-(1h-indol-3-yl)-(703-80-0) |
Safety information for 3-Acetylindole
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for 3-Acetylindole
3-Acetylindole manufacturer
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