3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

Synonym(s):Spleen Tyrosine Kinase Inhibitor, 3-(1-Methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide;Syk Inhibitor - CAS 622387-85-3 - Calbiochem

CAS NO.：622387-85-3
Empirical Formula: C18H15N3O3S
Molecular Weight: 353.39
MDL number: MFCD07776820
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-03 18:03:33

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE Structural

What is 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE?

Description

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC₅₀ value of 14 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC₅₀ = 313 nM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.

The Uses of 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

OXSI 2 is a Syk selective inhibitor.

What are the applications of Application

Syk Inhibitor is an inhibitor of FcεRI-mediated degranulation in RBL-2H3

Properties of 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Orange powder solid.
color	Light yellow to brown
Sensitive	Light Sensitive

Safety information for 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.

Computed Descriptors for 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

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