3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE

Synonym(s):3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide

CAS NO.：676599-90-9
Empirical Formula: C16H16N2O3
Molecular Weight: 284.31
MDL number: MFCD05865226
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-01 16:21:21

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Structural

What is 3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE?

Description

APHA compound 8 is an inhibitor of class I histone deacetylases (HDACs; IC₅₀s = 3.7, 7.4, 0.42, and 2.8 μM for HDAC1, -2, -3, and -8, respectively) as well as class II HDACs (IC₅₀s = 3.1, 0.1, 3.1, and 4.2 μM for HDAC4, -6, -7, and -10, respectively). It is selective for class I and II HDACs over class III HDACs (IC₅₀s = >30 μM for SIRT1, SIRT2, and SIRT3) and the histone acetyltransferase PCAF (IC₅₀ = >30 μM). At 48 hours post-infection, APHA compound 8 increases replication of oncolytic herpes simplex virus (oHSV) in MDA-MB-231 and 4T1 breast cancer cells when used prior to viral infection at concentrations of 10 and 50 μM.

What are the applications of Application

APHA Compound 8 is a synthetic HDAC (histone deacetylase) inhibitor

Properties of 3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE

storage temp.	2-8°C
solubility	DMSO: 10 mg/mL, soluble
form	solid

Safety information for 3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H317:Sensitisation, Skin H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for 3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE

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