2,6-Dimethoxybenzoic acid
- CAS NO.：1466-76-8
- Empirical Formula: C9H10O4
- Molecular Weight: 182.17
- MDL number: MFCD00002437
- EINECS: 215-985-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:01
What is 2,6-Dimethoxybenzoic acid?
Chemical properties
white to off-white crystalline powder. Hardly soluble in water, soluble in alkali and organic solvents, such as benzene and toluene.
The Uses of 2,6-Dimethoxybenzoic acid
2,6-Dimethoxybenzoic Acid is used in the synthesis of indoles as well as coumarins related to Novobiocin (N888500), used as potent inhibitors of heat-shock protein 90 in the treatment of breast cancer.
Preparation
2,6-Dimethoxybenzoic acid is the key intermediate in the preparation of gamma-resorcylic acid which has been described as having activity against rheumatic fever.
The Preparation of 2,6-Dimethoxybenzoic Acid
Cite this: J. Org. Chem. 1956, 21, 3, 368–369
Publication Date:March 1, 1956
https://doi.org/10.1021/jo01109a604
Definition
ChEBI: 2,6-Dimethoxybenzoic acid is a member of benzenes and a carbonyl compound. It is a polyphenol compound found in foods of plant origin.
Synthesis Reference(s)
Synthetic Communications, 22, p. 13, 1992 DOI: 10.1080/00397919208021074
Flammability and Explosibility
Not classified
Purification Methods
Crystallise the acid from water or 1,1-dichloroethane (m 187.5-188.5o). [Beilstein 10 H 388, 10 I 185, 10 II 259, 10 III 1401, 10 IV 1456.]
Properties of 2,6-Dimethoxybenzoic acid
| Melting point: | 185-187 °C (lit.) |
| Boiling point: | 275.56°C (rough estimate) |
| Density | 1.2481 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 14.7g/l soluble |
| pka | pK1:3.44 (25°C) |
| form | Crystalline Powder |
| color | White to off-white |
| Water Solubility | 0.35 g/100 mL (25 ºC) |
| BRN | 2212190 |
| CAS DataBase Reference | 1466-76-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 2,6-dimethoxy-(1466-76-8) |
| EPA Substance Registry System | Benzoic acid, 2,6-dimethoxy- (1466-76-8) |
Safety information for 2,6-Dimethoxybenzoic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,6-Dimethoxybenzoic acid
| InChIKey | MBIZFBDREVRUHY-UHFFFAOYSA-N |
2,6-Dimethoxybenzoic acid manufacturer
Seema Finechem Industry LLP
Mumbai
product: Variable 2,6- Dimethoxybenzoic Acid, Packaging Size: Standard
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![2-[(4,6-DIMETHOXYPYRIMIDIN-2-YL)OXY]-6-METHOXYBENZOIC ACID](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB5727654.gif)
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