2,6-Dichloro-5-fluoronicotinamide

CAS NO.：113237-20-0
Empirical Formula: C6H3Cl2FN2O
Molecular Weight: 209.01
MDL number: MFCD01571365
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-01 20:51:29

What is 2,6-Dichloro-5-fluoronicotinamide?

The Uses of 2,6-Dichloro-5-fluoronicotinamide

2,6-Dichloro-5-fluoronicotinamide is a fluorinated pharmaceutical intermediate compound used in the synthesis of Sotorasib and AMG 510. Sotorasib is a RAS GTPase family inhibitor used for the treatment of KRAS-mutated solid tumours including non-small cell lung cancer (NSCLC) and colorectal cancer.

Properties of 2,6-Dichloro-5-fluoronicotinamide

Melting point:	160-162
Boiling point:	259.0±40.0 °C(Predicted)
Density	1.614±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	13.36±0.50(Predicted)
form	crystalline solid
color	White
InChI	InChI=1S/C6H3Cl2FN2O/c7-4-2(6(10)12)1-3(9)5(8)11-4/h1H,(H2,10,12)

Safety information for 2,6-Dichloro-5-fluoronicotinamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection.