2,6-Bis[(4S)-phenyl-2-oxazolin-2-yl]pyridine
Synonym(s):(S,S)-2,6-Bis(4,5-dihydro-4-phenyl-2-oxazolyl)pyridine;(S,S)-2,6-Bis(4-phenyl-2-oxazolinyl)pyridine
- CAS NO.:174500-20-0
- Empirical Formula: C23H19N3O2
- Molecular Weight: 369.42
- MDL number: MFCD01863586
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-08 17:45:00
What is 2,6-Bis[(4S)-phenyl-2-oxazolin-2-yl]pyridine?
Chemical properties
White solid
What are the applications of Application
2,6-Bis[(4S)-4-phenyl-2-oxazolinyl]pyridine is used in chemical synthesis
Reactions
1. Ligand for Copper catalyzed syn-selective Mukaiyama aldol reaction.
2. Ligand for Tin catalyzed anti-selective aldol reaction.
3. Ligand for Ytterbuim catalyzed desymmetrization of meso epoxides.
4. Ligand for Copper catalyzed enantioselective addition of terminal alkynes to imines.
5. Ligand for Scandium catalyzed enantioselective syn-selective ene reactions.
6. Ligand for Copper catalysed asymmetric alkynylation of cyclic azomethine Imines.
7. Ligand for Europium catalyzed asymmetric alpha amination.
8. Ligand for Indium catalyzed enantioselective construction of spiro-fused 2-oxindole/α-methylene-γ-butyrolactones.
9. Ligand for Copper catalyzed asymmetric azide-alkyne cycloaddition to quaternary oxindoles.
10. Ligand for Iron catalyzed enantioselective nitrene transfer to sulfides.
11. Ligand for Copper catalyzed enantioselective intramolecular propargylic amination.
12. Ligand for Copper catalyzed asymmetric hydroxylation.
13. Ligand for Scandium catalyzed dearomatization of 2-naphthols by electrophilic amination.
14. Ligand for Copper catalyzed asymmetric alkynylation of oxocarbenium ions to set diaryl tetrasubstituted stereoceters.



Properties of 2,6-Bis[(4S)-phenyl-2-oxazolin-2-yl]pyridine
| Melting point: | 171-175 °C(lit.) |
| Boiling point: | 600.4±55.0 °C(Predicted) |
| alpha | -224 º (c=1, chloroform) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | crystal |
| pka | 3.07±0.70(Predicted) |
| color | white |
| optical activity | [α]20/D 224°, c = 1 in chloroform |
| Water Solubility | Insoluble |
| CAS DataBase Reference | 174500-20-0(CAS DataBase Reference) |
Safety information for 2,6-Bis[(4S)-phenyl-2-oxazolin-2-yl]pyridine
| Signal word | Warning |
| Pictogram(s) |
![]() Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,6-Bis[(4S)-phenyl-2-oxazolin-2-yl]pyridine
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