2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester
- CAS NO.：4684-32-6
- Empirical Formula: C20H22N2O3
- Molecular Weight: 338.4
- MDL number: MFCD11042254
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-16 07:06:08
What is 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester?
Description
An Alstonia alkaloid obtained from A. scholaris R. Br., this base also occurs in Rauwolfia vornitora. It has [α]D - 47° (CHCI3). The ultraviolet spectrum in neutral solution (EtOH) has absorption maxima at 237 and 287 mil, while in acidic solution (perchloric acid), there are absorption maxima at 239, 244 and 305 mil. A methoxycarbonyl group, an alkyl group and an ether bridge are present in the molecule. The picrate is obtained as light yellow crystals with m.p. 172- 4°C (dec.) and the methiodide has m.p. 235-7°C.
The Uses of 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester
Picrinine is a monoterpenoid indole alkaloid extracted from Ochrosia elliptica, displaing the enhancement of immunomodulatory activity and apaptosis inducing in the A549 cell lines.
References
Preparation:
Britten, Smith.,J. Chern. Soc., 3850 (1963)
Isolation:
Chatterjee et al., Tetrahedron Lett., 3633 (1965)
Properties of 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester
| Melting point: | 222-224 °C |
| Boiling point: | 501.1±50.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 4.47±0.40(Predicted) |
| color | White to off-white |
Safety information for 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester
Computed Descriptors for 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester
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