2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
- CAS NO.：59989-18-3
- Empirical Formula: C6H4N2O2
- Molecular Weight: 136.11
- MDL number: MFCD00871973
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:40:54
What is 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)?
Description
Eniluracil (59989-18-3) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor.1-3? DPD is involved in the degradation of pyrimidine-based chemotherapeutic drugs such as 5-fluorouracil (5-FU).? Eniluracil has been used along with 5-FU to prolong circulating concentrations of the drug.
The Uses of 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
Potent inactivator of Dihydropyrimidine dehydrogenase (DPD).
Definition
ChEBI: Eniluracil is a pyrimidone.
References
1) Porter?et al. (1992),?Mechanism-based Inactivation of Dihydropyrimidine Dehydrogenase by 5-Ethynyluracil; J. Biol. Chem.,?267?5236 2) Baccalnari?et al. (1993),?5-Ethynyluracil (776C85): a potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil; Proc. Natl. Acad. Sci. USA,?90?11064 3) Schilsky and Kindler (2000)?Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase; Expert Opin. Investig. Drugs,?9?1635
Properties of 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
| Melting point: | 320° (dec) |
| Density | 1.527 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in DMSO |
| form | solid |
| pka | 7.44±0.10(Predicted) |
| color | Yellow |
| λmax | 284nm(MeOH)(lit.) |
| Merck | 14,3584 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Safety information for 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,4(1H,3H)-Pyrimidinedione, 5-ethynyl- (9CI)
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