2,4-Dihydroxypyrimidine-5-carboxylic acid

Synonym(s):Isoorotic acid;Uracil-5-carboxylic acid

CAS NO.：23945-44-0
Empirical Formula: C5H4N2O4
Molecular Weight: 156.1
MDL number: MFCD00006023
EINECS: 245-947-2
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:45:10

2,4-Dihydroxypyrimidine-5-carboxylic acid Structural

What is 2,4-Dihydroxypyrimidine-5-carboxylic acid?

Chemical properties

white to slightly yellow crystalline powder or

The Uses of 2,4-Dihydroxypyrimidine-5-carboxylic acid

2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) has been used for the visual sensing of melamine (at parts-per-billion (ppb) level) by a highly sensitive analytical method based on Au nanoparticles.

What are the applications of Application

2,4-Dihydroxypyrimidine-5-carboxylic acid is has been used for the visual sensing of melamine

Definition

ChEBI: Uracil-5-carboxylic acid is a pyrimidinemonocarboxylic acid that is uracil carrying a carboxy group at position 5. It is functionally related to a uracil. It is a conjugate acid of a uracil-5-carboxylate. It is a tautomer of a 2,4-dihydroxypyrimidine-5-carboxylic acid.

General Description

2,4-Dihydroxypyrimidine-5-carboxylic acid (Uracil-5-carboxylic acid) has been obtained from 5-formyluracil by the action of enzyme, thymine 7-hydroxylase. It has been used to synthesize N1-alkylated uracil derivatives.

Properties of 2,4-Dihydroxypyrimidine-5-carboxylic acid

Melting point:	283 °C (dec.)(lit.)
Boiling point:	280.29°C (rough estimate)
Density	1.6814 (rough estimate)
refractive index	1.4800 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in DMSO
pka	5.08±0.20(Predicted)
form	Crystalline Powder
color	White to slightly yellow
Water Solubility	1.8g/L(20 ºC)
CAS DataBase Reference	23945-44-0(CAS DataBase Reference)
EPA Substance Registry System	5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo- (23945-44-0)

Safety information for 2,4-Dihydroxypyrimidine-5-carboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.