2,4-Dichloroaniline

CAS NO.：554-00-7
Empirical Formula: C6H5Cl2N
Molecular Weight: 162.02
MDL number: MFCD00007661
EINECS: 209-057-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 2,4-Dichloroaniline?

Chemical properties

pale grey or beige-brown to red-brown crystalline. Melting point 63°C, boiling point 245°C, relative density 1.567 (20/4°C), soluble in organic solvents such as ethanol, ether and acids. Slightly soluble in water. The color will be darkened in air.

The Uses of 2,4-Dichloroaniline

2,4-Dichloroaniline is used as an intermediate in the synthesis of dyestuffs, pigments, and pesticides.

The Uses of 2,4-Dichloroaniline

2,4-Dichloroaniline may be used as an analytical reference standard for the determination of the analyte in water samples by ultrasound-assisted ionic liquid dispersive liquid-phase micro-extraction, capillary electrophoresis with electrochemical and fluorescence detection and gas chromatography-mass spectrometry (GC-MS), respectively.

The Uses of 2,4-Dichloroaniline

2,4-Dichloroaniline is used as a raw material for the synthesis of anti-infective drug ciprofloxacin, pesticide fungicide Imibenconazole, herbicide (PUMA) and dyes.

Preparation

2,4-Dichloroaniline is synthesized from acetanilide by chlorination and hydrolysis.

Definition

ChEBI: 2,4-dichloroaniline is a dichloroaniline carrying chloro substituents at positions 2 and 4.

General Description

Beige crystals.

Air & Water Reactions

2,4-Dichloroaniline may be sensitive to exposure to air. Insoluble in water.

Reactivity Profile

2,4-Dichloroaniline is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents.

Fire Hazard

Flash point data for 2,4-Dichloroaniline are not available. 2,4-Dichloroaniline is probably combustible.

Properties of 2,4-Dichloroaniline

Melting point:	59-62 °C (lit.) 60-65 °C
Boiling point:	245 °C (lit.)
Density	1.567
vapor pressure	1hPa at 78℃
refractive index	1.6000 (estimate)
Flash point:	115°C
storage temp.	0-6°C
solubility	methanol: soluble, clear, very faintly brownish-yellow
form	Crystalline Powder
pka	2.05(at 22℃)
color	White to beige
Specific Gravity	1.567 (20℃)
Water Solubility	Insoluble, <0.1 g/100 mL at 23 ºC
BRN	386422
CAS DataBase Reference	554-00-7(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 2,4-dichloro-(554-00-7)
EPA Substance Registry System	2,4-Dichloroaniline (554-00-7)

Safety information for 2,4-Dichloroaniline

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.