2,6-Dichloropyridine

CAS NO.：2402-78-0
Empirical Formula: C5H3Cl2N
Molecular Weight: 147.99
MDL number: MFCD00006244
EINECS: 219-282-3
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:22

What is 2,6-Dichloropyridine?

Description

2,6-Dichloropyridine is an important intermediate that is widely used in the medicine and pesticide research field. It could be used as a starting material to synthesize the pirozadil (Pirozadil) which can be used for reducing blood-fat, and antiplatelet condensation. 2,6-dichloropyridine also can be used to synthetic musk pyridine with alternative natural musk. 2,3,5, 6-TCP produced by further chlorination of 2, 6-dichloropyridine is an important raw material for chlorpyrifos, which is widely used in the world with high efficiency, broad spectrum, and low residue.

Synthesis

2-chloropyridine or 2-chloropyridine hydrochloride reacting with chlorine under photoinitiation actions at 160-190 ℃ to generate the 2,6-dichloropyridine.

Chemical properties

White to light yellow solid

The Uses of 2,6-Dichloropyridine

2,6-Dichloropyridine is used in the preparation of triazolo and imidazo potassium channel antagonists as antiarrythmic agents.

Purification Methods

It crystallises from EtOH. [Beilstein 20/5 V 416.]

Properties of 2,6-Dichloropyridine

Melting point:	83-86 °C (lit.)
Boiling point:	211 °C
Density	1.5159 (rough estimate)
refractive index	1.5500 (estimate)
Flash point:	110°C
storage temp.	Inert atmosphere,2-8°C
solubility	methanol: 50 mg/mL, clear
form	Crystalline Powder
pka	-3.02±0.10(Predicted)
color	White to pink or grayish-white
PH	6-7 (H2O, 20℃)(saturated solution)
Water Solubility	<1 g/L (20 ºC)
BRN	108664
CAS DataBase Reference	2402-78-0(CAS DataBase Reference)
NIST Chemistry Reference	Pyridine, 2,6-dichloro-(2402-78-0)
EPA Substance Registry System	2,6-Dichloropyridine (2402-78-0)

Safety information for 2,6-Dichloropyridine

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.