2,3-Dimethoxy-5-methyl-p-benzoquinone
Synonym(s):Coenzyme Q0
- CAS NO.：605-94-7
- Empirical Formula: C9H10O4
- Molecular Weight: 182.17
- MDL number: MFCD00001595
- EINECS: 210-100-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:50
What is 2,3-Dimethoxy-5-methyl-p-benzoquinone?
Chemical properties
red or orange crystals or fibres
The Uses of 2,3-Dimethoxy-5-methyl-p-benzoquinone
2,3-Dimethoxy-5-methyl-p-benzoquinone (Ubidecarenone EP Impurity A)
What are the applications of Application
2,3-Dimethoxy-5-methyl-p-benzoquinone is used in the synthesis of a variety of polyprenylated quinones
Definition
ChEBI: A derivative of benzoquinone carrying a 5-methyl substituent; and methoxy substituents at positions 2 and 3. The core structure of the ubiquinone group of compounds.
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 16, p. 2343, 1968 DOI: 10.1248/cpb.16.2343
The Journal of Organic Chemistry, 53, p. 5453, 1988 DOI: 10.1021/jo00258a010
General Description
2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0 or DMM) is present in all the cells including neural cells.
Biochem/physiol Actions
2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0) interacts with tau protein and aids in the formation of filamentous structure.
Purification Methods
It crystallises in red needles from pet ether (b 40-60o) and sublimes at high vacuum at a bath temperature of 46-48o [Ashley et al. J Chem Soc 441 1938, UV in EtOH: Vischer J Chem Soc 815 1953, UV in cyclohexane: Morton et al. Helv Chim Acta 41 2343 1858, Aghoramurthy et al. Chem Ind (London) 1327 1954]. [Beilstein 8 IV 2721.]
Properties of 2,3-Dimethoxy-5-methyl-p-benzoquinone
| Melting point: | 58-60 °C(lit.) |
| Boiling point: | 331.4±42.0 °C(Predicted) |
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| Water Solubility | almost transparency in hot Water |
| solubility | DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.2 mg/ml |
| form | Crystalline Powder or Needles |
| color | Red to orange |
| Sensitive | Light Sensitive |
| BRN | 1640422 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, reducing agents. |
| CAS DataBase Reference | 605-94-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,5-Cyclohexadiene-1,4-dione, 2,3-dimethoxy-5-methyl-(605-94-7) |
Safety information for 2,3-Dimethoxy-5-methyl-p-benzoquinone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,3-Dimethoxy-5-methyl-p-benzoquinone
New Products
4-Iodo-3,5-dimethylbenzonitrile 2-fluoro-4-iodoaniline 2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 6,6'-methylenebis(9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one) 3-Bromo-2-fluorobenzoic acid Quinuclidine-4-carbonitrile N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (R)-1-Benzyl-3-pyrrolidinecarbonitrile Bupropian related compound F Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 1,4-bis(methylsulfonyl)butane 4-Cyano-N-Methacryloyl-3-Trifluoromethyl Aniline 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzeneRelated products of tetrahydrofuran
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