Senicapoc
- CAS NO.：289656-45-7
- Empirical Formula: C20H15F2NO
- Molecular Weight: 323.34
- MDL number: MFCD09027349
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is Senicapoc?
Description
Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.
The Uses of Senicapoc
Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist.
Properties of Senicapoc
| Melting point: | 180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2)) |
| Boiling point: | 460.7±45.0 °C(Predicted) |
| Density | 1.250±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO : 50 mg/mL (154.64 mM; Need ultrasonic) |
| form | Powder |
| pka | 15.41±0.50(Predicted) |
| color | White to yellow |
Safety information for Senicapoc
Computed Descriptors for Senicapoc
New Products
6-Methyl-2-(p-tolyl)imidazo[1,2-a]pyridine 4-FLUOROBENZOYLACETONITRILE (S)-Glycidyl Phthalimide Maleic hydrazide 8-Bromo-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid 4'-Hydroxyacetophenone 3-Bromophenylacetic acid Tridecanoic acid Pentadecanoic acid 3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Hendecanoic acid 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride 4-pyridine methanol Ethyl 3,3- diethoxypropionate 5-Bromo-pyridine-2-carbaldehyde 1-Bromo-3-phenylpropane 4-(4-Methylpiperazino)aniline 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate N-((S)-1-(3-(3-amino-4-chloro-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate 4-bromo-2-ethyl-3-fluorobenzoic acid 6-(chloromethyl)pteridine-2,4-diamine monohydrochloride 2-Chlorophenyl diphenyl chloromethaneRelated products of tetrahydrofuran
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