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HomeProduct name list20-HETE-D6

20-HETE-D6

  • CAS NO.：2548939-89-3
  • Empirical Formula: C20H32O3
  • Molecular Weight: 320.47
  • MDL number: MFCD05863966
  • Update Date: 2025-04-17 18:22:24
20-HETE-D6 Structural

What is 20-HETE-D6?

Description

20-HETE-d6 contains six deuterium atoms at the 16, 16', 17, 17', 18 and 18' positions. It is intended for use as an internal standard for the quantification of 20-HETE by GC- or LC-MS. 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature.1 In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction.2 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide.3

What are the applications of Application

20-HETE-d6 is an internal standard for quantification of 20-HETE by GC- or LC-mass spectrometry

References

1. McGiff, J.C., and Quilley, J. 20-HETE and the kidney: Resolution of old problems and new beginnings Am. J. Physiol. 277(3),R607-R623(1999).
2. Gebremedhin, D., Lange, A.R., Lowry, T.F., et al. Production of 20-HETE and its role in autoregulation of cerebral blood flow Circ. Res. 87(1),60-65(2000).
3. Prakash, C., Zhang, J.Y., Falck, J.R., et al. 20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine Biochem. Biophys. Res. Commun. 185(2),728-733(1992).

Properties of 20-HETE-D6

solubility  DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 500 μg/ml
form  Liquid
color  Colorless to light yellow

Safety information for 20-HETE-D6

Computed Descriptors for 20-HETE-D6

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