2-(TRIMETHYLSILYL)ETHANESULFONAMIDE, 90%
Synonym(s):SES-NH2
- CAS NO.：125486-96-6
- Empirical Formula: C5H15NO2SSi
- Molecular Weight: 181.33
- MDL number: MFCD09265152
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:09:26
What is 2-(TRIMETHYLSILYL)ETHANESULFONAMIDE, 90%?
The Uses of 2-(TRIMETHYLSILYL)ETHANESULFONAMIDE, 90%
2-Trimethylsilylethanesulfonyl amide is a useful reagent for introduction of a SES-protected nitrogen functionality, which can be cleaved with fluoride ion.
The Uses of 2-(TRIMETHYLSILYL)ETHANESULFONAMIDE, 90%
2-(Trimethylsilyl)ethanesulfonamide is a source of nucleophilic nitrogen that can react in manifold ways with electrophiles prior to removal of SES group with fluoride ion. It participates in the following reactions: Preparation of N-Sulfonylimines, Mitsunobu Reactions, Azaglycosylation Chemistry, Preparation of Sulfodiimides, Preparation of (N-SES-imino)phenyliodinane etc.
Preparation
2-(Trimethylsilyl)ethanesulfonamide is prepared by reaction of 2-(trimethylsilyl) ethanesulfonyl chloride (accessible from the commercially available sodium salt of the corresponding sulfonic acid or starting from vinyl trimethylsilane) with gaseous ammonia (eq 1).
Properties of 2-(TRIMETHYLSILYL)ETHANESULFONAMIDE, 90%
| Melting point: | 81-87 °C |
| Boiling point: | 253.0±42.0 °C(Predicted) |
| Density | 1.057±0.06 g/cm3(Predicted) |
| solubility | Soluble in benzene, chloroform, dichloromethane,
ether, methanol and toluene. |
| pka | 10.99±0.60(Predicted) |
Safety information for 2-(TRIMETHYLSILYL)ETHANESULFONAMIDE, 90%
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(TRIMETHYLSILYL)ETHANESULFONAMIDE, 90%
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