2-(Trifluoromethyl)benzyl bromide

Synonym(s):α′-Bromo-α,α,α-trifluoro-o-xylene

CAS NO.：395-44-8
Empirical Formula: C8H6BrF3
Molecular Weight: 239.03
MDL number: MFCD00013558
EINECS: 206-901-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-04 16:00:12

2-(Trifluoromethyl)benzyl bromide Structural

What is 2-(Trifluoromethyl)benzyl bromide?

Chemical properties

Colorless to light yellow liqui

The Uses of 2-(Trifluoromethyl)benzyl bromide

2-(Trifluoromethyl)benzyl bromide may be used in chemical synthesis.

Preparation

A solution of 30 ml of phosphorus tribromide in 60 ml of absolute toluene was added dropwise at 20°-30° C. to a solution of 14 g of o-trifluoromethylbenzyl alcohol in 80 ml of absolute toluene. Subsequently, the reaction mixture was stirred at room temperature for 2 hours, the toluene was distilled under reduced pressure, the residue was dissolved in methylene chloride, treated with water and the mixture was adjusted to pH 8.0 with potassium hydrogen carbonate. The aqueous phase was extracted three times with CH2Cl2 and the organic phases were washed twice with water and once with saturated NaCl solution, dried over Na2 SO4 and evaporated under reduced pressure. 2-(Trifluoromethyl)benzyl bromide was obtained as the residue.

Properties of 2-(Trifluoromethyl)benzyl bromide

Melting point:	34-35 °C
Boiling point:	72 °C (7.5 mmHg)
Density	1.571 g/mL at 25 °C(lit.)
refractive index	1.496-1.499
Flash point:	83 °C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	powder to lump to clear liquid
color	White or Colorless to Light yellow
Specific Gravity	1.571
Sensitive	Lachrymatory
BRN	2256977
CAS DataBase Reference	395-44-8(CAS DataBase Reference)
NIST Chemistry Reference	2-Trifluoromethylbenzyl bromide(395-44-8)

Safety information for 2-(Trifluoromethyl)benzyl bromide

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.