2-Quinolinol
Synonym(s):2-Quinolinol;Carbostyril
- CAS NO.：59-31-4
- Empirical Formula: C9H7NO
- Molecular Weight: 145.16
- MDL number: MFCD00006743
- EINECS: 200-420-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-06-19 09:04:31
What is 2-Quinolinol?
Chemical properties
white to light purple or purple-brownish powder
The Uses of 2-Quinolinol
2-Hydroxyquinoline was used to obtain the design of the platinum(IV) complexes with intense bands shifted towards longer wavelengths. The Pt(IV) complexes are inert stable prodrugs that were photoactivated to produce Pt(II) species with promising anticancer activity.
Definition
ChEBI: A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.
Synthesis Reference(s)
Synthesis, p. 739, 1975 DOI: 10.1055/s-1975-23918
General Description
2-Hydroxyquinoline is a specific inhibitor of plaque paraoxonase1 (PON1).
Purification Methods
Crystallise it from MeOH. It has m 200-201o after sublimation in a vacuum. The picrate has m 132o after crystallisation from Et2O. [Gibson et al. J Chem Soc 4340 1955, Beilstein 21 III/IV 1057, 21/8 V 217.]
Properties of 2-Quinolinol
| Melting point: | 198-199 °C (lit.) |
| Boiling point: | 264.27°C (rough estimate) |
| Density | 1.1555 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | alcohol: soluble(lit.) |
| form | Powder |
| pka | -0.31, 11.76(at 20℃) |
| color | White to light purple or purple-brownish |
| Water Solubility | 1.052g/L(20 ºC) |
| Merck | 14,1825 |
| BRN | 2855 |
| CAS DataBase Reference | 59-31-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 2(1H)-Quinolinone(59-31-4) |
| EPA Substance Registry System | 2(1H)-Quinolinone (59-31-4) |
Safety information for 2-Quinolinol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Quinolinol
2-Quinolinol manufacturer
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