2-PIPERIDYLMETHYLAMINE
Synonym(s):(RS)-1-(Piperidin-2-yl)methanamine;2-Piperidinemethanamine
- CAS NO.：22990-77-8
- Empirical Formula: C6H14N2
- Molecular Weight: 114.19
- MDL number: MFCD00129011
- EINECS: 245-371-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 2-PIPERIDYLMETHYLAMINE?
The Uses of 2-PIPERIDYLMETHYLAMINE
2-Piperidinemethanamine is used in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. It also is used in the synthesis of potent antibacterial.
The Uses of 2-PIPERIDYLMETHYLAMINE
Reactant for reversible aminal formation
Reactant for synthesis of:
- Annulated N-heterocyclic carbene ligands
- M3 Muscarinic receptor antagonists
- Selective 5-ht5A receptor antagonists
- Ternary platinum(II) complexes
What are the applications of Application
2-(Aminomethyl)piperidine is a simple piperidine & useful synthetic reagent
Purification Methods
Dry (over Na2SO4) and distil the piperidine under vacuum from KOH. It has been purified via the Reinekate salt (m 173-174o) and its dipicrate salt (m 201o, from H2O). [Norton et al. J Am Chem Soc 68 1330 1946, Mortimer Aust J Chem 11 84 1958, Augustine J Am Chem Soc 81 4667 1959, Beilstein 22 III/IV 3765.]
Properties of 2-PIPERIDYLMETHYLAMINE
| Boiling point: | 63-66°C/12mm |
| Density | 0.9406 g/mL at 25 °C |
| refractive index | 1.4850 |
| Flash point: | 63-66°C/12mm |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | neat |
| pka | 10.32±0.29(Predicted) |
| color | Clear Colorless |
| BRN | 102994 |
| CAS DataBase Reference | 22990-77-8(CAS DataBase Reference) |
Safety information for 2-PIPERIDYLMETHYLAMINE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-PIPERIDYLMETHYLAMINE
| InChIKey | RHPBLLCTOLJFPH-UHFFFAOYSA-N |
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