2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

Synonym(s):2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450;2-Chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]-phenol;L 779450;Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem

CAS NO.：303727-31-3
Empirical Formula: C20H14ClN3O
Molecular Weight: 347.8
MDL number: MFCD12828750
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-15 14:23:52

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole Structural

What is 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole?

The Uses of 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

Raf kinase inhibitor, a potential treatment for neurotraumatic diseases. Its effects also suppress DNA synthesis and induce apoptosis in targeted cells, presenting new applications in treating certain types of cancers.

What are the applications of Application

L-779,450 is a potent, ATP-competitive Raf kinase inhibitor

Definition

ChEBI: 2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol is a member of imidazoles.

Biological Activity

Potent, ATP-competitive Raf kinase inhibitor (IC 50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38 α , GSK3 β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.

Properties of 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

Boiling point:	579.8±50.0 °C(Predicted)
Density	1.335±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO:44.67(Max Conc. mg/mL);128.44(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);86.26(Max Conc. mM) DMF:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.35(Max Conc. mM) Ethanol:2.0(Max Conc. mg/mL);5.75(Max Conc. mM)
form	Powder
pka	8.09±0.10(Predicted)
color	Light yellow to yellow

Safety information for 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

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