2-Oxazolidone
- CAS NO.：497-25-6
- Empirical Formula: C3H5NO2
- Molecular Weight: 87.08
- MDL number: MFCD00005268
- EINECS: 207-840-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:00
What is 2-Oxazolidone ?
Chemical properties
off-white to yellow-beige crystals or powder
The Uses of 2-Oxazolidone
As an oxazole derivative used as an antibiotic, 2-Oxazolidone is also used in the preparation of compounds with antitumor activity and as a metabolite of Furazolidone (F864100).
The Uses of 2-Oxazolidone
An oxazole derivative used as an antibiotic. It is also used in the preparation of compounds with antitumor activity. A metabolite of Furazolidone (F864100).
Definition
ChEBI: An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2.
Safety Profile
Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Crystallise it from *benzene, dichloroethane, CHCl3 or EtOH. It is a cyclic urethane, and as such it is not very stable. [Katritzky et al. J Chem Soc Perkin II 145 1990, Beilstein 27 H 135, 27 II 259, 27 III/IV 2516.]
Properties of 2-Oxazolidone
| Melting point: | 83-87 °C(lit.) |
| Boiling point: | 220 °C48 mm Hg(lit.) |
| Density | 1.2736 (rough estimate) |
| refractive index | 1.4940 (estimate) |
| Flash point: | 220°C/48mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly, Heated), Methanol (Slightly) |
| form | Crystals or Powder |
| pka | 12.78±0.20(Predicted) |
| color | Off-white to yellow-beige |
| Water Solubility | Soluble in water. |
| BRN | 106251 |
| CAS DataBase Reference | 497-25-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Oxazolidin-2-one(497-25-6) |
| EPA Substance Registry System | 2-Oxazolidinone (497-25-6) |
Safety information for 2-Oxazolidone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-Oxazolidone
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