2'-O-MOE-A(Bz)-3'-phosphoramidite
- CAS NO.：251647-53-7
- Empirical Formula: C50H58N7O9P
- Molecular Weight: 932.01
- MDL number: MFCD29472587
- Update Date: 2026-01-13 11:26:03
What is 2'-O-MOE-A(Bz)-3'-phosphoramidite?
Description
2'-O-MOE-A(Bz)-3'-phosphoramidite, also known as DMT-2'-O-MOE-rA(Bz) phosphoramidite, inserts 2'-O-methoxyethyl-modified adenosine into oligonucleotide phosphoramidites for antisense RNA. Its 2'-MOE backbone bolsters duplex stability, nuclease resistance, and has low toxicity, contributing to effective, safe genetic manipulation. It is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
Chemical properties
The IUPAC name of 2'-O-MOE-A(Bz)-3'-phosphoramidite is (2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite. It is white to off-white powder.
The Uses of 2'-O-MOE-A(Bz)-3'-phosphoramidite
N6-Benzoyl-5''-O-DMT-2''-O-(2-methoxyethyl)adenosine 3''-CE phosphoramidite (CAS# 251647-53-7) is used diagnostically in the screening of insulin-like growth factor-I (IGF-I) and growth hormone receptor (GHR) oligonucleotidic modulators.
Properties of 2'-O-MOE-A(Bz)-3'-phosphoramidite
| pka | 7.87±0.43(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for 2'-O-MOE-A(Bz)-3'-phosphoramidite
Computed Descriptors for 2'-O-MOE-A(Bz)-3'-phosphoramidite
| InChIKey | VPBYBQBHLYRLHG-VCCSSPGHNA-N |
2'-O-MOE-A(Bz)-3'-phosphoramidite manufacturer
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