2'-O-Methylcytidine
- CAS NO.：2140-72-9
- Empirical Formula: C10H15N3O5
- Molecular Weight: 257.24
- MDL number: MFCD11519076
- EINECS: 2017-001-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-26 17:33:40
What is 2'-O-Methylcytidine?
Description
2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon, making it an effective viral replication inhibitor. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways and may be able to bind to the response element on DNA, which could inhibit protein synthesis in cancer cells. It is an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50 = 3.8 μM). It inhibits HCV replication in a replicon assay (IC50 = 21.2 μM).
Chemical properties
White powder
The Uses of 2'-O-Methylcytidine
2'-O-Methylcytidine is used in the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
The Uses of 2'-O-Methylcytidine
Cytidine analog.
What are the applications of Application
2′-O-Methylcytidine is a cytidine analog
Definition
ChEBI: 2'-O-methylcytidine is a methylcytidine.
Properties of 2'-O-Methylcytidine
| Melting point: | 252-253 C |
| Boiling point: | 506.0±60.0 °C(Predicted) |
| Density | 1.68±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO. |
| form | Powder |
| pka | 13.37±0.70(Predicted) |
| color | White to Off-white |
| InChI | InChI=1S/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1 |
| CAS DataBase Reference | 2140-72-9(CAS DataBase Reference) |
Safety information for 2'-O-Methylcytidine
Computed Descriptors for 2'-O-Methylcytidine
| InChIKey | RFCQJGFZUQFYRF-ZOQUXTDFSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OC)[C@@H]1O |
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