2-Methyl-5-nitropyridine
- CAS NO.：21203-68-9
- Empirical Formula: C6H6N2O2
- Molecular Weight: 138.12
- MDL number: MFCD04114179
- EINECS: 677-568-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-06-03 18:04:15
What is 2-Methyl-5-nitropyridine?
The Uses of 2-Methyl-5-nitropyridine
2-Methyl-5-nitropyridine is used as pharmaceutical intermediate.
Synthesis
2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester could be used as a starting material to synthesize 2-methyl-5-nitropyridine. The specific operations are as follows: To 2-(5-nitro-pyridin-2-yl)-malonic acid diethyl ester (12.0 g, 42.5 mmol) was added cold aq. 20% sulfuric acid (120 mL) and the mixture was heated to 100 ℃ for 2h. The cooled reaction was added to a cold dilute sodium hydroxide solution and the pH adjusted to 10. The organics were extracted with dichloromethane (x 4), and then the combined organic phases were dried over sodium sulfate. The filtrate was concentrated to afford 2-methyl-5-nitropyridine (5.0 g, 83 %) as a brown solid.
Properties of 2-Methyl-5-nitropyridine
| Melting point: | 112 C |
| Boiling point: | 237.1±20.0 °C(Predicted) |
| Density | 1.246±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 1.92±0.10(Predicted) |
| form | Solid |
| color | Light yellow to Brown |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C6H6N2O2/c1-5-2-3-6(4-7-5)8(9)10/h2-4H,1H3 |
| CAS DataBase Reference | 21203-68-9(CAS DataBase Reference) |
Safety information for 2-Methyl-5-nitropyridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-Methyl-5-nitropyridine
| InChIKey | USZINSZJSVMICC-UHFFFAOYSA-N |
| SMILES | C1(C)=NC=C([N+]([O-])=O)C=C1 |
2-Methyl-5-nitropyridine manufacturer
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product: 2-Methyl-5-nitropyridine 21203-68-9 98%
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