2-methyl-1,3-thiazole-5-carboxylic acid
- CAS NO.：40004-69-1
- Empirical Formula: C5H5NO2S
- Molecular Weight: 143.16
- MDL number: MFCD01760300
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:17:14
What is 2-methyl-1,3-thiazole-5-carboxylic acid?
Synthesis
To a stirred solution of 2-methyl-thiazole-5-carboxylic acid ethyl ester (1.3 g, 8.0 mmol) in dioxane (12 mL) at room temperature was added NaOH (2N, 12 mL). After 1 h the reaction mixture was neutralized with HCl (IN, 12 mL), then filtered and the collected solid dried in vacuo to give 2-methyl-1,3-thiazole-5-carboxylic acid (758 mg, 70percent) as an off white solid.
Properties of 2-methyl-1,3-thiazole-5-carboxylic acid
| Melting point: | 209 °C(Solv: water (7732-18-5)) |
| Boiling point: | 301.2±15.0 °C(Predicted) |
| Density | 1.418±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 3.78±0.10(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C5H5NO2S/c1-3-6-2-4(9-3)5(7)8/h2H,1H3,(H,7,8) |
Safety information for 2-methyl-1,3-thiazole-5-carboxylic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-methyl-1,3-thiazole-5-carboxylic acid
| InChIKey | QCXCIYPOMMIBHO-UHFFFAOYSA-N |
| SMILES | S1C(C(O)=O)=CN=C1C |
2-methyl-1,3-thiazole-5-carboxylic acid manufacturer
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