2-METHOXYBENZENETHIOL
Synonym(s):2-Mercaptoanisole;2-Methoxybenzenethiol;Thioguaiacol
- CAS NO.：7217-59-6
- Empirical Formula: C7H8OS
- Molecular Weight: 140.2
- MDL number: MFCD00004834
- EINECS: 230-605-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 2-METHOXYBENZENETHIOL?
Chemical properties
clear yellow liquid
Chemical properties
Colorless to yellowish liquid; pungent, onion aroma.
Occurrence
Reported found in coffee.
The Uses of 2-METHOXYBENZENETHIOL
2-Methoxythiophenol is used in the synthesis of berberine-thiophenyl hybrids as multifunctional agents. Inhibition of acetylcholinesterase, butyrylcholinesterase and AB aggregation antioxidant activity.
The Uses of 2-METHOXYBENZENETHIOL
2-Methoxythiophenol was used in the synthesis of:
- (4S)-N-[(2S)-2-methy-3-(2-methoxyphenylthio)propanoyl]-4-phenyloxazolidin-2-one
- 2-(4-fluorophenyl)-6-(2-methoxyphenylsulfanyl)imidazo[1,2-a]pyridine
- 2-(2-methoxyphenylsulfanyl)benzoic acid
Definition
ChEBI: 2-Methoxybenzenethiol is a thiol.
Aroma threshold values
Meaty type, very high strength odor, recommend smelling in a 0.10% solution or less.
Taste threshold values
Meaty sausage taste at 1 ppm in water.
General Description
2-Methoxythiophenol is a sulfur-containing compound that can be used as a flavoring agent.
Synthesis
2-Methoxybenzenethiol is prepared：
1) from or(ho-Aminophenol-methylether via
Diazoreaction.
2) from Sodium phenoxide plus Sulfur at
200° C. to yield 2: 2'-Dihydroxy-diphenyldisulfide.
Reduction and Methylation
afford the title ether.
Properties of 2-METHOXYBENZENETHIOL
| Melting point: | 306.7-313.7 °C (decomp) |
| Boiling point: | 99 °C/8 mmHg (lit.) |
| Density | 1.152 g/mL at 25 °C (lit.) |
| refractive index | n |
| FEMA | 4159 | 2-MERCAPTOANISOLE |
| Flash point: | 204 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | H2O: insoluble |
| pka | 6.62±0.43(Predicted) |
| form | Liquid |
| Specific Gravity | 1.152 |
| color | Clear yellow |
| Odor | at 1.00 % in propylene glycol. meaty smoked sausage powdery sweet spicy phenolic sulfurous |
| Sensitive | Stench |
| JECFA Number | 1666 |
| BRN | 2042178 |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 7217-59-6(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenethiol, 2-methoxy- (7217-59-6) |
Safety information for 2-METHOXYBENZENETHIOL
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-METHOXYBENZENETHIOL
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