2,5-Dimethoxythiophenol
Synonym(s):2,5-Dimethoxybenzenethiol
- CAS NO.：1483-27-8
- Empirical Formula: C8H10O2S
- Molecular Weight: 170.23
- MDL number: MFCD00052738
- EINECS: 626-652-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-11-04 16:48:04
What is 2,5-Dimethoxythiophenol?
Chemical properties
Clear colorless to Pale Yellow Oil
The Uses of 2,5-Dimethoxythiophenol
2,5-Dimethoxythiophenol is a thiophenol derivative used in the preparation of dihydrofolate reductase inhibitors and potential antitumor agents.
General Description
The s-alkylation of 2,5-dimethoxythiophenol with pentyl bromide and heptyl bromide was studied.
Properties of 2,5-Dimethoxythiophenol
| Melting point: | 248.3-252.0 °C (decomp) |
| Boiling point: | 88-90 °C/0.5 mmHg (lit.) |
| Density | 1.134 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform, Methanol |
| form | Oil |
| pka | 6.37±0.48(Predicted) |
| color | Clear colorless to Pale Yellow |
| Sensitive | Stench |
| BRN | 1867842 |
| CAS DataBase Reference | 1483-27-8(CAS DataBase Reference) |
Safety information for 2,5-Dimethoxythiophenol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,5-Dimethoxythiophenol
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