5-Bromo-2-hydroxymethylpyridine

CAS NO.：88139-91-7
Empirical Formula: C6H6BrNO
Molecular Weight: 188.02
MDL number: MFCD04035597
EINECS: 618-116-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 22:41:20

What is 5-Bromo-2-hydroxymethylpyridine?

Chemical properties

Light yellow Cryst

Synthesis

5-bromo-2-pyridinecarboxylic acid, methyl ester (648mg, 3mmol) in 10ml of methanol was slowly added to sodium borohydride (340mg, 9mmol) in an ice bath. After that, the ice bath was removed and the reaction mixture was warmed to room temperature. The reaction was stirred for 12 hours. Then 1N HCl was added to adjust the pH to 1. Afterward, a saturated sodium bicarbonate solution was added to adjust the pH to 8. The mixture was then extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. This resulted in the formation of 535mg of white solid, which was identified as 5-bromo-2-pyridinemethanol. The yield of the desired product was 94.8%.
2-Hydroxymethyl-5-bromopyridine

Properties of 5-Bromo-2-hydroxymethylpyridine

Melting point:	59-60°C
Boiling point:	0°C
Density	1.668±0.06 g/cm3(Predicted)
Flash point:	0°C
storage temp.	Inert atmosphere,Room Temperature
form	powder to crystal
pka	13.09±0.10(Predicted)
color	White to Light yellow to Light orange
InChI	InChI=1S/C6H6BrNO/c7-5-1-2-6(4-9)8-3-5/h1-3,9H,4H2
CAS DataBase Reference	88139-91-7(CAS DataBase Reference)

Safety information for 5-Bromo-2-hydroxymethylpyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention.