2-Fluorobenzoic acid
- CAS NO.：445-29-4
- Empirical Formula: C7H5FO2
- Molecular Weight: 140.11
- MDL number: MFCD00002405
- EINECS: 207-158-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:19:32
What is 2-Fluorobenzoic acid?
Chemical properties
white to light yellow crystal powder. soluble in organic solvents such as benzene, toluene, ketone and ether.The corresponding 2-fluorobenzoyl chloride can be obtained by reacting 2-fluorobenzoic acid with an acid chloride agent such as SOCl2, PCl3, etc.
The Uses of 2-Fluorobenzoic acid
2-Fluorobenzoic acid is an intermediate of the fungicide tritriazole and meclofenamic acid.
The Uses of 2-Fluorobenzoic acid
2-Fluorobenzoic acid may be employed in the preparation of zaragozic acid A analogs. It is also used as an organic chemical synthesis intermediate.
Definition
ChEBI: 2-fluorobenzoic acid is a 2-halobenzoic acid that is benzoic acid carrying a fluoro substituent at position 2. It is a fluorobenzoic acid and a 2-halobenzoic acid. It is a conjugate acid of a 2-fluorobenzoate.
Preparation
The preparation of 2-fluorobenzoic acid is based on anthranilic acid as raw material, adding anhydrous hydrogen fluoride and sodium nitrite in methoxyethyl methyl ether solvent for diazotization, refluxing for 3 hours, and post-processing to obtain the finished product.
Purification Methods
Crystallise the acid from 50% aqueous EtOH, dilute HCl or *C6H6, then purify it by zone melting or vacuum sublimation at 130-140o. [Beilstein 9 H 333. 9 III 1324, 9 IV 950.]
Properties of 2-Fluorobenzoic acid
| Melting point: | 122-125 °C (lit.) |
| Boiling point: | 114 °C |
| Density | 1,46 g/cm3 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 7.2g/l |
| form | Crystalline Powder or Needles |
| pka | 3.27(at 25℃) |
| color | White to light yellow |
| Water Solubility | Slightly soluble in water. |
| BRN | 971265 |
| InChI | InChI=1S/C7H5FO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10) |
| CAS DataBase Reference | 445-29-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 2-fluoro-(445-29-4) |
| EPA Substance Registry System | Benzoic acid, 2-fluoro- (445-29-4) |
Safety information for 2-Fluorobenzoic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 2-Fluorobenzoic acid
| InChIKey | NSTREUWFTAOOKS-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=CC=C1F |
2-Fluorobenzoic acid manufacturer
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