2-Ethylphenol

CAS NO.：90-00-6
Empirical Formula: C8H10O
Molecular Weight: 122.16
MDL number: MFCD00002249
EINECS: 201-958-4
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:27:12

What is 2-Ethylphenol?

Chemical properties

2-Ethylphenol is a colorless liquid. It is one of three isomeric ethylphenols. It has been used as a reagent for the synthesis of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists for the treatment of diabetes mellitus. 2-Ethylphenol has also been used in the preparation of aminoquinazoline-like toll receptor ligands and for potential immunotherapy.

The Uses of 2-Ethylphenol

2-Ethylphenol is used as a reagent in the synthesis of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists used in the treatment of diabetes. It is also used in the preparation of aminoquinazolines as Toll-like receptor 4 ligands and potential immunotherapeutics.

Definition

ChEBI: 2-Ethylphenol is a member of phenols.

Preparation

2-Ethylphenol is produced by ethylation of phenol using ethylene or ethanol in the presence of aluminium phenolate. It is a natural product found in Cichorium endivia, Saussurea involucrata, and other organisms with data available.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Human toxic action similar to, but less severe than, that of phenol. Questionable carcinogen with experimental neoplastigenic data. When heated to decomposition it emits acrid smoke and irritating fumes. See also PHENOL

Purification Methods

Purify as for p-ethylphenol below. [Beilstein 6 H 470, 6 IV 3011.]

Properties of 2-Ethylphenol

Melting point:	-18 °C (lit.)
Boiling point:	195-197 °C (lit.)
Density	1.037 g/mL at 25 °C (lit.)
refractive index	n20/D 1.536(lit.)
Flash point:	78 °C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	pK1:10.2 (25°C)
form	clear liquid
color	Colorless to Light yellow
Water Solubility	insoluble
Merck	14,3839
BRN	1099397
Stability:	Stable. Combustible. Incompatible with acid chlorides, acid anhydrides, oxidizing agents.
CAS DataBase Reference	90-00-6(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 2-ethyl-(90-00-6)
EPA Substance Registry System	o-Ethylphenol (90-00-6)

Safety information for 2-Ethylphenol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.