2-Ethylhexyl 4-dimethylaminobenzoate

Absorption

Padimate O is capable of human skin penetration .

Toxicity

Padimate O causes DNA strand breaks of cells under the epidermis in vitro . No LD50 value reported.

Chemical properties

Colorless to yellow liquid

The Uses of 2-Ethylhexyl 4-dimethylaminobenzoate

Ultraviolet screen Arlatone.

The Uses of 2-Ethylhexyl 4-dimethylaminobenzoate

padimate O is the drug name for ethylhexyl dimethyl PABA, a sunscreen chemical formerly known as octyl dimethyl PABA.

The Uses of 2-Ethylhexyl 4-dimethylaminobenzoate

2-ethylhexyl-4-dimethyl-amino-benzoate is used as an UV-B-absorbing agent in sunscreens and cosmetic creams, lotions, lipsticks, sun oils, moisturizers, nail polish, etc.

Background

Padimate O is an active sunscreen agent in cosmetics and over-the-counter sunscreen drug products in concentrations up to 8%, as regulated by the FDA . It is a structurally-related compound to Aminobenzoic acid that absorbs UV-B rays to prevent photodamage. It penetrates human skin, and is shown to induce non-ligatable strand breaks on DNA in vitro and mutagenic effects on yeast in vivo .

Indications

Indicated as an active UV-B filter to prevent photodamage.

Definition

ChEBI: Padimate O is a benzoate ester.

General Description

Padimate O is a tertiary amine derivative of p-aminobenzoic acid (PABA), which is commonly used as a sunscreen agent in cosmetics and other sunscreen formulations due to its ability to absorb ultraviolet radiations.

Pharmacokinetics

Padimate O absorbs UV-B rays, which can in turn induce DNA damage in human keratinocytes. While treatment of padimate O suppresses the formation of UV-endonuclease-sensitive sites, there is also an increase in direct strand breaks of DNA in cells .

Metabolism

No pharmacokinetic data available.