2-DIMETHYLAMINO-4,5,6,7-TETRABROMO-1H-BENZIMIDAZOLE

Synonym(s):2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole;4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine;4,5,6,7-Tetrabromo-N,N-dimethyl-1H-benzo[d]imidazol-2-amine;CK2 Inhibitor II;DMAT

Empirical Formula: C9H7Br4N3
Molecular Weight: 476.78798
MDL number: MFCD08705322

2-DIMETHYLAMINO-4,5,6,7-TETRABROMO-1H-BENZIMIDAZOLE Structural

What is 2-DIMETHYLAMINO-4,5,6,7-TETRABROMO-1H-BENZIMIDAZOLE?

Biological Activity

High affinity, cell-permeable inhibitor of casein kinase 2 (CK2) (K i = 40 nM; IC 50 = 0.13 μ M). Displays no activity at CK1 at concentrations up to 200 μ M. Also inhibits Pim kinase (IC 50 values are 0.097, 0.148 and 1.6 μ M for Pim-3, Pim-1 and Pim-2 kinase respectively), and protein kinase D1 (IC 50 = 0.18 μ M). Derivative of TBB (4,5,6,7-Tetrabromobenzotriazole).

Safety information for 2-DIMETHYLAMINO-4,5,6,7-TETRABROMO-1H-BENZIMIDAZOLE

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CASEIN KINASE II