2-Diethylaminoethylchloride hydrochloride
Synonym(s):2-(Diethylamino)ethyl chloride hydrochloride;2-Chloro-N,N-diethylethylamine hydrochloride;2-Chlorotriethylamine hydrochloride
- CAS NO.：869-24-9
- Empirical Formula: C6H15Cl2N
- Molecular Weight: 172.1
- MDL number: MFCD00012519
- EINECS: 212-786-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:18:28
What is 2-Diethylaminoethylchloride hydrochloride?
Chemical properties
2-Diethylaminoethylchloride hydrochloride is colourless to beige crystals
The Uses of 2-Diethylaminoethylchloride hydrochloride
2-Diethylaminoethylchloride hydrochloride is used as intermediate for the syntheses of pharmaceuticals (e.g. amiodarone, butetamate citrate, flurazepam and naftidrofuryl). Product Data Sheet
The Uses of 2-Diethylaminoethylchloride hydrochloride
2-Chloro-N,N-diethylethylamine hydrochloride (65% in water) (DEC 65) is used as intermediate for the syntheses of pharmaceuticals (e.g. amiodarone, butetamate citrate, flurazepam and naftidrofuryl). Product Data Sheet
The Uses of 2-Diethylaminoethylchloride hydrochloride
2-Chloro-N,N-diethylethylamine hydrochloride can be used as an alkylating reagent for the synthesis of:
- Substituted oxindole derivatives to be used as growth hormone secretagogs.
- 1-Substituted-5,6-dinitrobenzimidazoles with antimicrobial and antiprotozoal activities.
- Thiophene containing triarylmethane (TRAM) derivatives to be used as antitubercular agents.
- Tris(2-(diethylamino)ethyl)amine to be used as a catalyst in combination with CuBr (Et6TREN/CuBr) for atom transfer radical polymerization of n-butyl acrylate.
It can also be used for the derivatization of chitosan to incorporate aminofunctionality onto it at C-6 position.
Purification Methods
Crystallise the salt from absolute MeOH (to remove highly coloured impurities). [Beilstein 4 III 240.]
Properties of 2-Diethylaminoethylchloride hydrochloride
| Melting point: | 50-53 °C(lit.) |
| Boiling point: | 255 °C(lit.) |
| Density | 1.1919 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.6000 (estimate) |
| Flash point: | 186 °F |
| storage temp. | Poison room |
| solubility | methanol: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| color | White to slightly beige |
| PH | 5 (100g/l, H2O, 20℃) |
| Water Solubility | 2000 g/L (20 ºC) |
| Sensitive | Moisture Sensitive |
| BRN | 3591991 |
| Stability: | Hygroscopic, Moisture Sensitive |
| CAS DataBase Reference | 869-24-9(CAS DataBase Reference) |
| EPA Substance Registry System | Diethyl-(2-chloroethyl)amine hydrochloride (869-24-9) |
Safety information for 2-Diethylaminoethylchloride hydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H300:Acute toxicity,oral H314:Skin corrosion/irritation H341:Germ cell mutagenicity H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Diethylaminoethylchloride hydrochloride
| InChIKey | RAGSWDIQBBZLLL-UHFFFAOYSA-N |
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