2'-Deoxyguanosine

Synonym(s):2′-Deoxyguanosine hydrate;9-(2-Deoxy-β-D-ribofuranosyl)guanine;Guanine-2′-deoxyriboside

CAS NO.：961-07-9
Empirical Formula: C10H13N5O4
Molecular Weight: 267.24
MDL number: MFCD00080300
EINECS: 213-505-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-29 14:06:09

What is 2'-Deoxyguanosine?

Chemical properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

The Uses of 2'-Deoxyguanosine

2'-Deoxyguanosine (Deoxyguanosine; dG) is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. It is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

Definition

ChEBI: 2'-deoxyguanosine is a purine 2'-deoxyribonucleoside having guanine as the nucleobase. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside. It is functionally related to a guanosine.

Purification Methods

2'-Deoxyguanosine recrystallises from H2O as the monohydrate. [Brown &C5440 Lythgoe J Chem Soc 1990 1950, L

Properties of 2'-Deoxyguanosine

Melting point:	300 °C
Boiling point:	410.43°C (rough estimate)
Density	1.3382 (rough estimate)
refractive index	-42 ° (C=0.2, 1mol/L NaOH)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	NH₄OH 1 M: 50 mg/mL, clear to very faintly turbid, yellow to brown
form	powder
pka	9?+-.0.20(Predicted)
color	White to Off-white
Water Solubility	Slightly soluble in water.
BRN	39814
CAS DataBase Reference	961-07-9(CAS DataBase Reference)
NIST Chemistry Reference	Deoxyguanosine(961-07-9)
EPA Substance Registry System	Guanosine, 2'-deoxy- (961-07-9)

Safety information for 2'-Deoxyguanosine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to..…