2'-deoxy-2'-fluoro-2'-C-methylcytidine

CAS NO.：817204-33-4
Empirical Formula: C10H14FN3O4
Molecular Weight: 259.23
MDL number: MFCD13176566
EINECS: 200-001-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-05 14:33:18

What is 2'-deoxy-2'-fluoro-2'-C-methylcytidine?

Description

PSI-6130 is a nucleoside inhibitor of the NS5B RNA polymerase of hepatitis C virus (HCV; K_i = 4.3 μM). It inhibits HCV genotype 1b (GT-1b) Con1 and GT-1a H77 viral replication in Huh7 replicon cells using a luciferase-based assay (EC₅₀s = 0.51 and 0.30 μM, respectively). PSI-6130 also inhibits replication of HCV GT-1b and GT-1a replicons from clinical isolates, with EC₅₀ values ranging from 0.60 to 1.41 μM, and 0.20 to 0.43 μM, respectively, in the same assay. It has little or no activity against West Nile Virus (WNV), Dengue type 2 virus (DV), human immunodeficiency virus (HIV), or hepatitis B virus (HBV; EC₉₀s = 46.3, >100, >100, and >10 μM, respectively).

The Uses of 2'-deoxy-2'-fluoro-2'-C-methylcytidine

PSI-6130 is an experimental treatment for hepatitis C. PSI-6130 is a member of a class of antiviral drugs known as nucleoside polymerase inhibitors. PSI-6130 inhibits the hepatitis C virus RNA dependant RNA polymerase called NS5B.

Properties of 2'-deoxy-2'-fluoro-2'-C-methylcytidine

Melting point:	216-218℃
Boiling point:	482.4±55.0 °C(Predicted)
Density	1.67
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Methanol (Slightly), Water (Slightly)
form	Solid
pka	12.86±0.70(Predicted)
color	White to Light Brown
Stability:	Hygroscopic

Safety information for 2'-deoxy-2'-fluoro-2'-C-methylcytidine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.