2-Cyano-5-methoxypyridine

CAS NO.：89809-63-2
Empirical Formula: C7H6N2O
Molecular Weight: 134.14
MDL number: MFCD08543467
EINECS: 200-589-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 01:27:06

What is 2-Cyano-5-methoxypyridine?

What are the applications of Application

5-Methoxypyridine-2-carbonitrile is a building block for research

Synthesis

To a mixture of 2-cyano-5-hydroxy pyridine (200 mg, 1.66 mmol), DMF (10 mL) and K2CO3 (253 mg, 1.83 mmol), was added MeI (354 mg, 2.49 mmol) at room temperature and the reaction mix was stirred for 24 h at room temperature. The reaction mix was poured into water and extracted with ethyl acetate. The organic layer was separated, washed with water, dried and concentrated to give 2-Cyano-5-methoxypyridine (175 mg, 78% yield).

Properties of 2-Cyano-5-methoxypyridine

Boiling point:	292.1±20.0 °C(Predicted)
Density	1.16±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	-4.06±0.10(Predicted)

Safety information for 2-Cyano-5-methoxypyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H332:Acute toxicity,inhalation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection.