2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
Synonym(s):Salicyl chlorophosphite;SalPCl
- CAS NO.：5381-99-7
- Empirical Formula: C7H4ClO3P
- Molecular Weight: 202.53
- MDL number: MFCD00013353
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:17:29
What is 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE?
Chemical properties
White Crystalline Solid
The Uses of 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is a reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. It is also reactive cyclic phosphitylating reagent involved in fast coupling rates and hydrolytic cleavage more readily compare to that of a acyclic analog.
The Uses of 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs
The Uses of 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
2-Chloro-1,3,2-benzodioxaphosphorin-4-one is used as a reagent:
- In the phosphorylation and phosphitylation of alcohols.
- In the formation of H-phosphonates which are commonly utilized in the synthesis of nucleotides.
- To synthesize nucleoside triphosphates by treating with acyl protected nucleoside.
Properties of 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
| Melting point: | 36-40 °C (lit.) |
| Boiling point: | 127-128 °C/11 mmHg (lit.) |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| solubility | Soluble in acetonitrile, dichloromethane, tetrahydrofuron and dimethylformamide. |
| form | solid |
| color | White or Colorless to Orange to Green |
| BRN | 1311951 |
| Stability: | Water Sensitive |
| CAS DataBase Reference | 5381-99-7(CAS DataBase Reference) |
Safety information for 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
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