2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE

Synonym(s):Salicyl chlorophosphite;SalPCl

CAS NO.：5381-99-7
Empirical Formula: C7H4ClO3P
Molecular Weight: 202.53
MDL number: MFCD00013353
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 02:46:49

2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE Structural

What is 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE?

Chemical properties

White Crystalline Solid

The Uses of 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE

2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is a reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. It is also reactive cyclic phosphitylating reagent involved in fast coupling rates and hydrolytic cleavage more readily compare to that of a acyclic analog.

The Uses of 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE

Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs

The Uses of 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE

2-Chloro-1,3,2-benzodioxaphosphorin-4-one is used as a reagent:

In the phosphorylation and phosphitylation of alcohols.
In the formation of H-phosphonates which are commonly utilized in the synthesis of nucleotides.
To synthesize nucleoside triphosphates by treating with acyl protected nucleoside.

Properties of 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE

Melting point:	36-40 °C (lit.)
Boiling point:	127-128 °C/11 mmHg (lit.)
Flash point:	>230 °F
storage temp.	2-8°C
solubility	Soluble in acetonitrile, dichloromethane, tetrahydrofuron and dimethylformamide.
form	solid
color	White or Colorless to Orange to Green
BRN	1311951
Stability:	Water Sensitive
CAS DataBase Reference	5381-99-7(CAS DataBase Reference)

Safety information for 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.