2-Bromopropionic acid

Chemical properties

clear colorless to yellowish liquid after melting. soluble in water, miscible with alcohol, ether, chloroform and benzene.

The Uses of 2-Bromopropionic acid

2-Bromopropionic Acid is a versatile reactant used in emulsion polymerization in the preparation of reversible addition-fragmentation chain transfer (RAFT) agent.

The Uses of 2-Bromopropionic acid

It is employed as pharmaceutical and agrochemical intermediate. It is used as an alkylation agent for mercaptans and other sulfur containing compounds.

What are the applications of Application

2-bromopropionic acid is an organic synthesis intermediate, used in the production of herbicides quizalofop-ethyl, napropamide, fenthiaprop and fungicides metalaxyl, benalaxyl, procymidone, etc., used in the synthesis of pharmaceutical intermediates body alanine.

Preparation

2-Bromopropionic acid is obtained by bromination of propionic acid. Add propionic acid and phosphorus trichloride to the reaction kettle, keep the temperature at 80°C, slowly add bromine to the reaction solution dropwise, and heat up to 85°C after the addition of bromine, and raise the temperature to 100°C when the color of bromine disappears completely, it takes about 2~3h, and then the bromine and hydrobromic acid are recovered under reduced pressure, and then the finished product is obtained by distillation under reduced pressure.

Synthesis Reference(s)

Tetrahedron Letters, 13, p. 4067, 1972 DOI: 10.1016/S0040-4039(01)94239-X