(2-Bromo-2-ethylbutyryl)urea

Chemical properties

white crystalline powder

Originator

Antineuralgiae,Jelfa

Definition

ChEBI: Carbromal is a N-acylurea.

Manufacturing Process

120 parts urea and 258 parts 2-bromo-2-ethylbutyrylbromide was mixed and stood at room temperature for 12 hours; then the mixture was heated about 3 hours on water bath and adjusted to alkaline pH with sodium bicarbonate after cooling. The unreacted products was dissolved in brine, the insoluble part was filtered off. The recrystallization from ethanol gave the title product - (2-bromo-2-ethyl-butyryl)urea as the colorless, odorless crystals. MP 114°- 118°C.

brand name

Adalin (Sterling Winthrop).

Therapeutic Function

Hypnotic, Sedative

General Description

Odorless tasteless white crystalline powder. Saturated solution in water neutral to litmus.

Air & Water Reactions

May be sensitive to prolonged exposure to air and light. Insoluble in water.

Reactivity Profile

The neat material may be sensitive to prolonged exposure to air and light. (2-BROMO-2-ETHYLBUTYRYL)UREA is incompatible with acids and alkalis.

Fire Hazard

Flash point data for (2-BROMO-2-ETHYLBUTYRYL)UREA are not available; however, (2-BROMO-2-ETHYLBUTYRYL)UREA is probably combustible.

Safety Profile

Poison by ingestion, subcutaneous, and possibly other routes. Moderately toxic via intravenous and intraperitoneal routes. Mutation data reported. A sedative, hypnotic, and central Intdious system depressant. When heated to decomposition it emits very toxic fumes of NOx and Br-.