2-Azetidinone
Synonym(s):β-Propiolactam;2-Azacyclobutanone
- CAS NO.：930-21-2
- Empirical Formula: C3H5NO
- Molecular Weight: 71.08
- MDL number: MFCD00013328
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:42:16
What is 2-Azetidinone?
The Uses of 2-Azetidinone
2-Azetidinone was used in synthesis of optically pure densely functionalized γ-lactams.
What are the applications of Application
2-Azetidinone is an unsubstituted four membered lactam
Definition
ChEBI: An unsubstituted beta-lactam compound.
General Description
2-Azetidinone is an unsubstituted four membered lactam. 2-Azetidinone is the fundamental building block of β-lactam antibiotics. X-ray photoelectron spectra of 2-azetidinone was investigated. 2-Azetidinone undergoes hydrolysis with aqueous alkali to yield β-alanine.
Properties of 2-Azetidinone
| Melting point: | 74-76 °C (lit.) |
| Boiling point: | 106 °C/15 mmHg (lit.) |
| Density | 1.0347 (rough estimate) |
| refractive index | 1.4035 (estimate) |
| storage temp. | 2-8°C |
| solubility | chloroform: very soluble(lit.) |
| form | Liquid |
| pka | 15.86±0.20(Predicted) |
| color | Clear |
| BRN | 104563 |
| InChI | InChI=1S/C3H5NO/c5-3-1-2-4-3/h1-2H2,(H,4,5) |
| CAS DataBase Reference | 930-21-2(CAS DataBase Reference) |
Safety information for 2-Azetidinone
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Azetidinone
| InChIKey | MNFORVFSTILPAW-UHFFFAOYSA-N |
| SMILES | N1CCC1=O |
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