Methyl 2-Aminothiazole-4-carboxylate

CAS NO.：118452-04-3
Empirical Formula: C5H6N2O2S
Molecular Weight: 158.18
MDL number: MFCD00622441
EINECS: 692-464-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-08-08 17:45:00

What is Methyl 2-Aminothiazole-4-carboxylate?

Chemical properties

Yellow Solid

The Uses of Methyl 2-Aminothiazole-4-carboxylate

Methyl 2-Aminothioazole-4-carboxylate (cas# 118452-04-3) is a compound useful in organic synthesis.

Synthesis

A solution of methyl 3-bromo-2-oxo-propanoate (10 g, 51 mmol) and thiourea (4.0 g, 552 mmol) in EtOH (200 mL) was added CuOAc (0.3 g, 2.62 mmol), then stirred at room temperature for 10 h. The mixture was concentrated to give the crude product (16 g). The crude product was basified with NaHC03 to pH=8, then extracted with EtOAc (200 mL x 3). The organic layer was washed with H20 (100 mL) and brine (100 mL), and then dried over anhydrous Na2S04, and then concentrated to give the product Methyl 2-Aminothiazole-4-carboxylate (8.0 g) as a yellow solid.

Properties of Methyl 2-Aminothiazole-4-carboxylate

Melting point:	160-164
Boiling point:	298.7±13.0 °C(Predicted)
Density	1.408±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Water
form	Solid
pka	2.46±0.10(Predicted)
color	Yellow
InChI	InChI=1S/C5H6N2O2S/c1-9-4(8)3-2-10-5(6)7-3/h2H,1H3,(H2,6,7)
CAS DataBase Reference	118452-04-3(CAS DataBase Reference)

Safety information for Methyl 2-Aminothiazole-4-carboxylate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.