2-Amino-5-chlorophenol
- CAS NO.：28443-50-7
- Empirical Formula: C6H6ClNO
- Molecular Weight: 143.57
- MDL number: MFCD02093863
- EINECS: 249-020-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 06:30:25
What is 2-Amino-5-chlorophenol?
Chemical properties
light brown fine crystalline powder
The Uses of 2-Amino-5-chlorophenol
2-Amino-5-chlorophenol may be used to synthesize 2-amino-5-chloromuconic semialdehyde and benzoxazole derivatives.
Definition
ChEBI: Phenol carrying amino and chloro substituents at positions 2 and 5 respectively. It is part of the degradation pathway of 4-chloronitrobenzene, CHEBI:34399.
General Description
2-Amino-5-chlorophenol can be synthesized from 2-chloro-5-nitrophenol via reduction. It can also be obtained from 1-chloro-4-nitrobenzene by using a bacterial strain LW1. 2-Amino-5-chlorophenol participates in the condensation reaction with acetylferrocene to afford ferrocenyl Schiff bases bearing a phenol group.
Properties of 2-Amino-5-chlorophenol
| Melting point: | 145-153 °C (lit.) |
| Boiling point: | 185.5°C (rough estimate) |
| Density | 1.2028 (rough estimate) |
| vapor pressure | 0.002-0.094Pa at 20-50℃ |
| refractive index | 1.5618 (estimate) |
| solubility | soluble in Methanol |
| form | Powder |
| pka | 8.79±0.10(Predicted) |
| color | Light brown |
| CAS DataBase Reference | 28443-50-7(CAS DataBase Reference) |
| EPA Substance Registry System | Phenol, 2-amino-5-chloro- (28443-50-7) |
Safety information for 2-Amino-5-chlorophenol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Amino-5-chlorophenol
2-Amino-5-chlorophenol manufacturer
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