2-Amino-5-chlorobenzoic acid

Synonym(s):5-Chloroanthranilic acid

CAS NO.：635-21-2
Empirical Formula: C7H6ClNO2
Molecular Weight: 171.58
MDL number: MFCD00007838
EINECS: 211-230-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 17:22:23

What is 2-Amino-5-chlorobenzoic acid?

Chemical properties

White to light yellow crystal powder

The Uses of 2-Amino-5-chlorobenzoic acid

2-Amino-5-chlorobenzoic acid is used in the preparation of disease-modifying antirheumatic drugs (DMARDs). Also used to produce 6-chloro-3H-quinazolin-4-one at temperature of 180°C.

The Uses of 2-Amino-5-chlorobenzoic acid

2-Amino-5-chlorobenzoic acid is a chlorinated derivative of antharilic acid,it is a metabolite of the pesticide Chlordimeform and it is used in the preparation of disease-modifying antirheumatic drugs (DMARDs).

The Uses of 2-Amino-5-chlorobenzoic acid

5-Chloroanthranilic Acid is a chlorinated derivative of anthranilic acid. 5-Chloroanthranilic Acid is a metabolite of the pesticide Chlordimeform. 5-Chloroanthranilic Acid is used in the preparation o f disease-modifying antirheumatic drugs (DMARDs).

Definition

ChEBI: 2-amino-5-chlorobenzoic acid is a member of the class of chlorobenzoic acids that is benzoic acid in which the ring hydrogens at positions 2 and 5 are replaced by amino and chloro groups, respectively. It is an aminobenzoic acid, a member of monochlorobenzenes and a chlorobenzoic acid.

Properties of 2-Amino-5-chlorobenzoic acid

Melting point:	204-206 °C (dec.) (lit.)
Boiling point:	250°C (rough estimate)
Density	1.3246 (rough estimate)
refractive index	1.5560 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	4.57±0.10(Predicted)
color	White to Pale Grey
Water Solubility	Soluble in water.
BRN	639027
CAS DataBase Reference	635-21-2(CAS DataBase Reference)
NIST Chemistry Reference	Benzoic acid, 2-amino-5-chloro-(635-21-2)
EPA Substance Registry System	Benzoic acid, 2-amino-5-chloro- (635-21-2)

Safety information for 2-Amino-5-chlorobenzoic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.