2-Amino-4-(trifluoromethyl)pyridine

CAS NO.：106447-97-6
Empirical Formula: C6H5F3N2
Molecular Weight: 162.11
MDL number: MFCD00077455
EINECS: 634-596-4
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 2-Amino-4-(trifluoromethyl)pyridine?

The Uses of 2-Amino-4-(trifluoromethyl)pyridine

2-Amino-4-trifluoromethylpyridine is a 2-amino-substituted nitrogen-containing six-membered heterocyclic compound, which is used as an important pharmaceutical intermediate.

Synthesis

2-Amino-4-(trifluoromethyl)pyridine can be synthesized by chemical reaction of 2-fluoro-4-trifluoromethyl-pyridine, acetamidine hydrochloride, NaOH, H2O and dimethyl sulfoxide under certain conditions.

Properties of 2-Amino-4-(trifluoromethyl)pyridine

Melting point:	70-74 °C
Boiling point:	221.3±40.0 °C(Predicted)
Density	1.368±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Powder, Solid or Crystalline
pka	4.55±0.11(Predicted)
color	White to pale brown
BRN	7869677
CAS DataBase Reference	106447-97-6(CAS DataBase Reference)

Safety information for 2-Amino-4-(trifluoromethyl)pyridine

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H300:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.