2-Amino-4-methoxy-6-methylpyrimidine

Chemical properties

white to pinkish or light beige

The Uses of 2-Amino-4-methoxy-6-methylpyrimidine

2-Amino-4-methoxy-6-methylpyrimidine may be employed as nucleophile to investigate the regioselective introduction of some nucleophiles at the secondary position of Baylis-Hillman adducts. It may be used in the preparation of 2-amino-4-methoxy-6-methylpyrimidin-1-ium picrate.

General Description

2-Amino-4-methoxy-6-methylpyrimidine (AMMP) is a pyrimidine derivative. It acts as electron donor and forms charge transfer complexes with iodine (σ-electron acceptor). The FTIR and FT-Raman spectra of 2-amino-4-methoxy-6-methylpyrimidine have been recorded to evaluate the energy, structural and thermodynamical parameters. Molecules of AMMP exhibit space group of Pnma and are joined by two N-H…N hydrogen bonds.

Purification Methods

Recrystallise it from H2O. The picrate has m 220-221o(dec). [Baker et al. J Am pKEst ~ Chem Soc 69 3072, 3075 1947, Sirakawa et al. Yakugaku Zasshi 73 598 1953, Backer & Grevenstuk Recl Trav Chim, Pays-Bas 61 291 1942, Beilstein 25 III/IV 3385.]