2-Amino-3-bromo-6-chloropyrazine
- CAS NO.：212779-21-0
- Empirical Formula: C4H3BrClN3
- Molecular Weight: 208.44
- MDL number: MFCD11044158
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-16 09:52:20
What is 2-Amino-3-bromo-6-chloropyrazine?
The Uses of 2-Amino-3-bromo-6-chloropyrazine
2-amino-3-bromo-6-chloropyrazine has essential applications in the pharmaceutical industry and is an important intermediate for synthesizing an anti-tumor medicament SHP2 inhibitor.
Preparation
Currently, in thepreparing 2-amino-3-bromo-6-chloropyrazine, the 2-amino-6-chloropyrazine is mainly obtained by a one-step bromination reaction. According to the method, bromine is mainly positioned at an amino para position due to the activation effect of amino; generated byproducts are mainly 2-bromo-3-chloro-5-aminopyrazine and partial dibromo byproduct 2-amino-3, 5-dibromo-6-chloropyrazine, the product 2-amino-3-bromo-6-chloro is less, the yield is low. A process for preparing 2-amino-3-bromo-6-chloropyrazine uses 3-aminopyrazine-2-carboxylate as raw material and includes such steps as chlorination, diazotization bromination, ester hydrolysis, carboxyl rearrangement and removing tert-butyloxycarbonyl.
Properties of 2-Amino-3-bromo-6-chloropyrazine
| Boiling point: | 299.5±35.0 °C(Predicted) |
| Density | 1.960 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 0.05±0.10(Predicted) |
Safety information for 2-Amino-3-bromo-6-chloropyrazine
Computed Descriptors for 2-Amino-3-bromo-6-chloropyrazine
New Products
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