2-AG-D8
- CAS NO.：924894-97-3
- Empirical Formula: C23H30D8O4
- Molecular Weight: 386.6
- MDL number: MFCD02259351
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-28 20:33:29
What is 2-AG-D8?
Description
2-Arachidonoyl glycerol-d8 (2-AG-d8) is intended for use as an internal standard for the quantification of 2-AG by GC- or LC-MS. 2-AG is an endogenous agonist of the CB1 receptor. Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in rat brain. Formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C and diacylglycerol lipase. 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a receptor-dependent mechanism.
Definition
ChEBI: 2-arachidonoylglycerol is an endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol. It has a role as a human metabolite. It is an endocannabinoid and a 2-acylglycerol 20:4. It is functionally related to an arachidonic acid.
Properties of 2-AG-D8
| solubility | DMSO: 10 mg/ml; Ethanol: Miscible; PBS (7.2): ~150 μg/ml |
| form | Liquid |
| color | Colorless to light yellow |
Safety information for 2-AG-D8
Computed Descriptors for 2-AG-D8
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