2-Adamantanamine hydrochloride
Synonym(s):2-Adamantanamine hydrochloride;2-Aminoadamantane hydrochloride
- CAS NO.：10523-68-9
- Empirical Formula: C10H18ClN
- Molecular Weight: 187.71
- MDL number: MFCD00074743
- EINECS: 234-074-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-04 16:04:00
What is 2-Adamantanamine hydrochloride?
Chemical properties
white crystalline powder
The Uses of 2-Adamantanamine hydrochloride
2-Adamantanamine Hydrochloride can be used to prepare CD73 inhibitors to treat CD73-associated diseases, including cancer and immune-related disorders.
The Uses of 2-Adamantanamine hydrochloride
2-Adamantylamine hydrochloride was used to prepare 2-adamantylamide of 2?-(carboxymethoxime)-olivomycin I. The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
General Description
The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied.
Purification Methods
The free amine in Et2O, liberated by the action of alkali in H2O, is dried over KOH, filtered, evaporated and sublimed at 110o/12torr, m 230-236o. The base is dissolved in EtOH, sufficient ethanolic HCl is added dropwise and crystallised by the addition of Et2O. Dry it in vacuo. [Stetter et al. Justus Liebigs Ann Chem 658 151 1962].
Properties of 2-Adamantanamine hydrochloride
| Melting point: | >300 °C(lit.) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Crystalline Powder |
| color | White |
| Water Solubility | soluble |
| BRN | 4297901 |
| InChI | InChI=1/C10H17N.ClH/c11-10-8-2-6-1-7(4-8)5-9(10)3-6;/h6-10H,1-5,11H2;1H/t6-,7+,8-,9+,10?; |
| CAS DataBase Reference | 10523-68-9(CAS DataBase Reference) |
Safety information for 2-Adamantanamine hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Adamantanamine hydrochloride
| InChIKey | WLDWDRZITJEWRJ-ZDAMNCSYNA-N |
| SMILES | C1(N)[C@@]2([H])C[C@]3([H])C[C@]([H])(C2)C[C@@]1([H])C3.Cl |&1:2,5,8,12,r| |
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