2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
- CAS NO.：1030825-20-7
- Empirical Formula: C18H14BrFS
- Molecular Weight: 361.27
- MDL number: MFCD21496340
- EINECS: 807-103-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-14 12:08:39
What is 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene?
The Uses of 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene is an antidiabetic agent that can be used to prepare Canagliflozin (C175190), a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.
Preparation
A preparation method for 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene, is characterized in that comprising the steps:
1) 2-bromothiophene and P-Bromofluorobenzene obtain 2-(4-fluorophenyl) thiophene by linked reaction;
2) 2-(4-fluorophenyl) thiophene and 2-methyl-5-bromo-benzoic acid obtain the bromo-2-aminomethyl phenyl of 5--2-(4-fluorophenyl) thiophene ketone by Friedel-Crafts reaction;
3) 5-bromo-2-aminomethyl phenyl-2-(4-fluorophenyl) thiophene ketone obtains 2-(the bromo-2-methyl-benzyl of 5-)-5-(4-fluorophenyl) thiophene through reduction reaction.
Properties of 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
| Melting point: | 103 °C |
| Boiling point: | 438.3±40.0 °C(Predicted) |
| Density | 1.388 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly, Heated), Hexanes (Slightly, Heated) |
| form | Solid |
| color | White to Off-White |
Safety information for 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
Computed Descriptors for 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene manufacturer
A.J Chemicals
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