2-(4-Hydroxy-3-methoxyphenyl)benzothiazole
- CAS NO.：36341-25-0
- Empirical Formula: C14H11NO2S
- Molecular Weight: 257.31
- MDL number: MFCD00030231
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:53:50
What is 2-(4-Hydroxy-3-methoxyphenyl)benzothiazole?
Biological Activity
YL-109 is a novel antitumor agent that inhibits the growth and invasion of breast cancer cells in vitro and in vivo.
in vitro
YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells.
Cell Proliferation Assay
| Cell Line: | < td class="col2"> MCF-7 and MDA-MB-231 cells|
| Concentration: | 0.001, 0.01, 0.1, 1, 10 μM |
| Incubation Time: | 96 hours |
| Result: | Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively). |
in vivo
YL-109 (15 mg/kg; sc for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo.
< /p>
| Animal Model: | BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells |
| Dosage: | 15 mg/kg |
| Administration: < /td> | Sc every 2 days for 63 days |
| Result: | Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells. |
Properties of 2-(4-Hydroxy-3-methoxyphenyl)benzothiazole
| storage temp. | 2-8°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml; Ethanol: 1 mg/ml |
| form | A crystalline solid |
| color | Light yellow to yellow |
Safety information for 2-(4-Hydroxy-3-methoxyphenyl)benzothiazole
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-(4-Hydroxy-3-methoxyphenyl)benzothiazole
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