2-(2-BOC-AMINOETHOXY)ETHANOL

Synonym(s):[2-(2-Hydroxyethoxy)ethyl]carbamic acid 1,1-dimethylethyl ester;N-[2-(2-Hydroxyethoxy)ethyl]carbamic acid tert-butyl ester;tert-Butyl[2-(2-hydroxyethoxy)ethyl]carbamate;2-(2-tert-Butoxycarbonylaminoethoxy)ethanol

CAS NO.：139115-91-6
Empirical Formula: C9H19NO4
Molecular Weight: 205.25
MDL number: MFCD04038542
SAFETY DATA SHEET (SDS)
Update Date: 2025-11-18 17:49:23

What is 2-(2-BOC-AMINOETHOXY)ETHANOL?

Description

N-Boc-PEG2-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

The Uses of 2-(2-BOC-AMINOETHOXY)ETHANOL

2-[2-(Boc-amino)ethoxy]ethanol is N-terminal protected 2-(2-aminoethoxy)ethanol. It is generally used as a molecular spacer/linker. Some of such applications are:

Synthesis of biotinylated HaloLigands to prepare quantum dot adducts for HaloTag protein-mediated specific labeling of live cells.
It is one of the key precursors for the total synthesis of tyroscherin and photo-activatable tyroscherin-based affinity reagent used for identification of tyroscherin binding proteins.
It can be used to link HaloTag enzyme with fluorescent zinc indicator, ZIMIR to monitor the dynamics of regulated secretion of zinc in real time.
It can also be used to synthesize amphiphiles for DNA and siRNA delivery.

Properties of 2-(2-BOC-AMINOETHOXY)ETHANOL

Boiling point:	332.9±22.0 °C(Predicted)
Density	1.061 g/mL at 25 °C
refractive index	n20/D1.454
Flash point:	>110℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	clear liquid
pka	12.20±0.46(Predicted)
color	Colorless to Light orange to Yellow

Safety information for 2-(2-BOC-AMINOETHOXY)ETHANOL

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.